Trigonelline
Catalog No: CFN90225
Trigonelline (1-methylpyridinium-3-carboxylate), an alkaloid present in coffee and fenugreek seed, exhibits phytoestrogenic, anti-adipogenesis, and anticancer activities, it also can reduce early glucose and insulin responses. Trigonelline has inhibition of the Nrf2 transcription factor and PPAR-γ.
Sesamol
Catalog No: CFN90452
Sesamol is regarded as a major antioxidant component in the oil with chemoprevention, radioprotective efficacy, anti-antiinflammary, antimutagenic, and antihepatotoxic activities. Sesamol inhibits melanin biosynthesis by down-regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis-related proteins through modulation of MITF activity, which promotes phosphorylation of p38 and JNK in melan-a cells.
Vinpocetine
Catalog No: CFN90467
Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. Vinpocetine can attenuate neointimal formation in diabetic rats and inhibit HG-induced VSMCs proliferation, chemokinesis and apoptotic resistance by preventing ROS activation and affecting MAPK, PI3K/Akt, and NF-κB signaling.Vinpocetine has anti-inflammatory activity, can treat inflammation and pain induced by a gram-negative bacterial component by targeting NF-κB activation and NF-κB-related cytokine production in macrophages.